Skip to main content

Abciximab - mechanism of action/ indication/ contraindication/ dose

It is a Fab fragment of a humanized monoclonal antibody directed against the glycoprotein IIb/IIIa. The latter is a platelet surface integrin. It is a receptor for fibrinogen which binds platelets to each other causing aggregation.


By inhibiting the receptor, abciximab acts as a potent antiplatelet agent. 

Indications:
1) myocardial ischemia,
2) percutaneous coronary intervention.

Dose:
1) For M.I - initially an I.V bolus of 0.25 mg/kg over 5 min followed by 0.125 µg/kg/min (to a maximum of 10 µg/min) for 12 hours.
2) For P.C.I - initially, 0.25 mg/kg I.V bolus over 5 min 20-60 min prior to angioplasty followed by 0.125 µg/kg/min (to a maximum of 10 µg/min) for next 12 hours.

Contraindications:
1) bleeding disorder or use of anticoagulant within 7 days,
2) CVA within 2 years,
3) known allergy to this product,
4) major trauma or surgery within 6 weeks,
5) severe uncontrolled hypertension,
6) active internal bleeding,
7) thrombocytopenia i.e platelet count < 100,000/ µL.

Labels

Labels:

Comments

  1. UnknownMay 29, 2017 at 9:40 AM

    I GOT CURED FROM HERPES WITHIN 8 DAYS, AFTER USING DR ADAGHE HERBAL MEDICINE.

    My name is Mrs Lisa Willard am out here to testify about how Dr Adaghe cured my (HERPES SIMPLEX VIRUS) i visited different hospital but they gave me list of drugs which were expensive to treat the virus but to no avail. I was browsing through the Internet searching for remedy on HERPES and i saw comment of people talking about how Dr Adaghe them. when i contacted him he gave me hope and send a Herbal medicine to me which i first thought wont solve anything but later i gave it a try and it seriously worked, my HERPES result came out negative. I am so happy as i am sharing this testimony. My advice to you all who thinks that their is no cure for herpes and also no genuine spell caster that is Not true just contact him and get cured today Dr Adaghe spell shrine can cure all kinds of sickness.Remember delay in treatment leads to death email him @ {doctoradaghebalhome@gmail.com}.


    HE IS ALSO SPECIALIZED IN THE TREATMENT OF VARIOUS AILMENT
    1 HIV/AIDS VIRUS
    2 CANCER DISEASE
    3 TUMOR DISEASE ETC
    HE CAN ALSO PROVIDE SOLUTION TO THE FOLLOWING LIFE PROBLEM
    1 EATING AND LOVE MAKING IN DREAM
    2 MASTURBATION ETC
    EMAIL HIM TODAY @ doctoradaghebalhome@gmail.com

    ReplyDelete

Post a Comment

Popular posts from this blog

Hypokalemia - Potassium replacement calculation

 DEFINITION  Hypokalemia is defined as a serum potassium level of less than 3.5 mmol/L. Normal level= 3.5-5.5 mmol/L. It is encountered in >20% of patients. Patients are usually asymptomatic but severe arrhythmias and rhabdomyolysis can occur. Non-specific complaints include easy fatiguability and skeletal muscle weakness. The preferred method of replacement is via the oral route but at times this is not possible. The article below will give you an idea about how to calculate the amount of KCl to be given I.V. 1) Potassium deficit in mmol is calculated as given below: K deficit  (mmol) = (K normal lower limit  - K measured ) x kg body weight x 0.4 2) Daily potassium requirement is around 1 mmol/Kg body weight. 3) 13.4 mmol of potassium found in 1 g KCl . ( molecular weight KCl = 39.1 + 35.5 = 74.6) Suppose we get an asymptomatic patient of  70 Kg with a serum potassium level of 3.0 mmol/L and he is on nil by mouth but having...
50 comments
Read more

Endomysium, Perimysium and epimysium - definition, histology

Each muscle fibre is closely surrounded by connective tissue. This acts as a support for the muscle fibres and unites them to each other. 1) Each muscle fibres is surrounded by delicate connective tissue that is called the endomysium . 2) Individual fasciculi are enclosed by a stronger sheath of connective tissue called the perimysium . 3) The entire muscle is surrounded by connective tissue called the epimysium . This is illustrated by the schematic diagram below. 1= perimysium, 2= endomysium, 3= fasciculus. At the junction of a muscle with a tendon, the fibres of the endomysium, the perimysium and the epimysium become continuous with the fibres of the tendon. First published on: 27 December 2016
Post a Comment
Read more

The plantar reflex - Babinski's sign

The plantar response is an important test to identify an upper motor neuron lesion.  PROCEDURE  To elicit it, the muscles of the lower limbs must be relaxed. The outer edge of the sole of the foot is stimulated by firmly scratching a blunt object like a key or a stick along it from the heel towards the little toe. This is what  Joseph Babinski did in the year 1896. He described the 'great toe sign' that year and then in 1903 the 'toe abduction or fan sign'. Nowadays, a final medial movement across the sole of the metatarsus is also done. i.e. we start at the heel to the little toe and finally arcing to the big toe. The final arcing movement is absent in the original Babinski plantar response test. Babinski sign refers to a combination of 'the great toe sign' and the 'fan sign'.  SIGNIFICANCE  The normal response is plantar flexion of the toes (down going) and they are drawn together. More precisely, there is flexion of the big toe and addu...
4 comments
Read more

Edema - Definition, pathophysiology, causes, clinical features

 DEFINITION  Edema is an abnormal presence of excessive fluid in the interstitial space.  PATHOPHYSIOLOGY  The movement of water and low molecular weight solutes such as salts between the intravascular and interstitial spaces is controlled primarily by the opposing effect of vascular hydrostatic pressure and plasma colloid osmotic pressure. Normally the outflow of fluid from the arteriolar end of the microcirculation into the interstitium is nearly balanced by inflow at the venular end. A small residual amount of fluid may be left in the interstitium and is drained by the lymphatic vessels, ultimately returning to the bloodstream via the thoracic duct. Either increased capillary pressure, diminished colloid osmotic pressure or inadequate lymphatic drainage can result in an abnormally increased interstitial fluid i.e. edema. An abnormal increase in interstitial fluid within tissues is called edema, while fluid collections in the different body cavi...
5 comments
Read more

Gram staining - Procedure, mechanism, explanation

 INTRODUCTION  The Gram stain was developed in 1884 by the Danish bacteriologist Hans Christian Gram. It is one of the most useful staining procedures because it classifies bacteria into two large groups:  1) gram-positive and  2) gram-negative.  PROCEDURE  1) A heat-fixed smear is flooded with a basic purple dye, usually crystal violet. Because the purple stain imparts its color to all cells, it is referred to as a primary stain . 2) After 1 minute, the crystal violet is drained off and washed with distilled water. The smear is then covered with Gram's iodine, a mordant or helper . When the iodine is washed off, both gram-positive and gram-negative bacteria appear dark violet or purple. 3) Next, the slide is washed with alcohol (95% ethanol) or an alcohol-acetone solution. This solution is a decolorizing agent which removes the purple from the cells of some species but not from others. When the procedure is carried out, the slide is held ...
3 comments
Read more